Sheri Yang and Michael Mitchell Awarded $2.79 Million NIH Grant to Study New Treatment for Rheumatoid Arthritis

Penn Dental Medicine’s Shuying (Sheri) Yang, a professor in the department of basic & translational sciences, and collaborator Michael Mitchell, an associate professor of bioengineering in Penn Engineering, have been awarded a $2.79 million grant over five years from the National Institutes of Health (NIH) to study a possible new treatment for rheumatoid arthritis (RA). Their collaboration was catalyzed by Penn Dental Medicine’s Center for Innovation & Precision Dentistry (CiPD), a joint center with Penn Engineering.
Affecting approximately 1% of the global population, RA is a severe autoimmune disorder that leads to chronic pain, inflammation, and joint destruction. Current treatments often fall short, with reportedly up to 40% of patients failing to respond effectively, while biologic therapies leave 6-21% of patients resistant to treatment.
“There is an urgent need for more effective treatments that target the underlying mechanisms of RA,” said Dr. Yang. “Our research focuses on the critical role of Inositol polyphosphate-5-phosphatase E (INPP5E), a 5-phosphatase that plays significant physiological roles in embryonic development, neurological function, the immune system, and blood cell proliferation and function.”
To date, their findings reveal that INPP5E expression is significantly reduced in the cells that play a pivotal role in RA pathogenesis. Through cutting-edge mouse models, it has been demonstrated that overexpression of INPP5E in macrophages reduces inflammation and bone destruction, suggesting that INPP5E is a potential internal protector against RA.
The innovative aspect of their project lies in the development of a novel delivery system using lipid nanoparticles (LNPs), enabling targeted delivery of INPP5E mRNA specifically to cells in the lining and sub-lining tissue of joints. “This approach offers a breakthrough in RA treatment by enhancing precision in drug delivery and maximizing anti-inflammatory effects,” said Dr. Yang. “Our targeted mRNA therapy not only inhibits key inflammatory pathways, but also mitigates bone erosion, presenting a dual therapeutic benefit.”
By bridging molecular insights and innovative drug delivery technologies, this project aims to transform the landscape of RA management. It holds significant promise for advancing RA treatment by offering a novel therapeutic strategy that could lead to more effective, targeted interventions for patients who do not respond to current therapies.
J. Margo Brooks Carthon: Director of Penn Nursing’s Bates Center for the Study of the History of Nursing
J. Margo Brooks Carthon, the Tyson Family Endowed Term Chair for Gerontological Research in Penn Nutsing; professor of nursing in the department of family and community health; and associate director of the Center for Health Outcomes and Policy Research, has been appointed the new director of the Barbara Bates Center for the Study of the History of Nursing, the preeminent history of nursing research center and archive. The Bates Center amplifies the importance of the history of nursing and healthcare to the development of crafting effective health policies and strategies to improve health for all.
“The evolution of the Bates Center continues to be a source of pride for us at Penn Nursing,” said Penn Nursing dean Antonia M. Villarruel. “Dr. Brooks Carthon brings expertise in an array of research methods including historical approaches, health services, and implementation science aimed at advancing health equity. Her leadership will build on the legacy of faculty who were foundational in creating this important resource for historians of nursing and beyond. Working collaboratively with Penn Libraries and Bates curator Jessica Martucci, I am confident that nursing history will live beyond the archives and continue to inform policy and practice. Dr. Brooks Carthon scholarly work exemplifies what is possible.”
“As the Bates Center director, I look forward to honoring the nursing profession’s historic contributions to addressing health inequities by integrating equity as a core value, one which will help to prioritize our collections, initiatives and collaborations,” said Dr. Brooks Carthon. “I recognize that advancing population health and achieving health equity requires a multipronged approach which brings together historians with clinicians, health services researchers, community participatory practitioners, innovators, and change agents from all backgrounds. I look forward to the Bates Center being a home where scholars from diverse perspectives can engage creatively to support bold and transformational ideas to improve population health locally, nationally, and internationally.”
The Bates Center is committed to providing the broadest and highest quality scholarship and educational programs and is equally committed to disseminating research findings through publications and interdisciplinary sharing and collaborations. By these means, the Bates Center dedicates itself to a leadership role in advancing the public’s knowledge of the history of nursing and healthcare.
Its goals are to:
- Advance knowledge in the history of nursing and healthcare.
- Engage with scholars whose research aligns with the mission of the center, the school, the University, and the pressing needs of healthcare systems in our nation and around the globe.
- Maximize the visibility, accessibility, and scope of the center’s historical collections.
Through its extensive collections, fellowships, and curricular opportunities, the Bates Center provides considerable evidence for scholars and students to question traditional disciplinary paradigms; to give voice to the historical power of nursing; and to analyze the strengths and weaknesses of local and global approaches to issues of health and illness. It is a committed partner in preserving all voices of nursing history, opening access to collection materials, and growing Penn’s digitized collections and sites.
Vaughn A. Booker: George E. Doty, Jr. and Lee Spelman Doty Presidential Associate Professor of Africana Studies in SAS
Vaughn A. Booker has been named the George E. Doty, Jr. and Lee Spelman Doty Presidential Associate Professor of Africana Studies in the School of Arts & Sciences. Dr. Booker is a historian of religion whose scholarship and teaching center on 20th-century African American religions. He focuses on people who engage in practices of simultaneously (re)making religious and racial identities, communities, and forms of authority. His teaching interests, which incorporate intersectional approaches, include Black religion and culture during Jim Crow, religion and the Civil Rights movement, contemporary Black religious/spiritual memoirs, religion and mourning/memorialization, and modern Black religious/spiritual communities.
Dr. Booker’s first book, Lift Every Voice and Swing: Black Musicians and Religious Culture in the Jazz Century, won the Council of Graduate Schools’ 2022 Gustave O. Arlt Award in the Humanities and was a finalist for the American Academy of Religion’s 2021 Religion and the Arts Book Award. His other academic publications have appeared in The Journal of Africana Religions, Religion and American Culture: A Journal of Interpretation, and Nova Religio: The Journal of Alternative and Emergent Religions. Dr. Booker co-chairs the Afro-American Religious History Unit of the American Academy of Religion. In 2022-2023, he was a distinguished junior external faculty fellow of the Stanford University Humanities Center and the recipient of a National Endowment for the Humanities fellowship. He was selected as one of 10 junior religion faculty nationwide to be in the 2019-2020 cohort of the Young Scholars in American Religion Program.
Lee Spelman Doty, W’76, and George E. Doty, Jr., W’76, established the George E. Doty, Jr., and Lee Spelman Doty Presidential Professorship in 2021. Ms. Doty is an Emeritus University Trustee and member of the Trustees’ Council of Penn Women. She previously served as Vice Chair of the Board of Trustees and president of the Penn Alumni Association. In 2022, she received the Alumni Award of Merit. She is currently vice chair of global equities at JP Morgan Asset Management. Mr. Doty has served for many years on his class reunion committee. In addition to the endowed professorship, they have supported key initiatives across campus over the years, including undergraduate scholarships, graduate student support, and the Presidential Engagement Prize.
Patrick Walsh: William Warren Rhodes-Robert J. Thompson Professor of Chemistry in SAS
Patrick Walsh, a professor of chemistry in the School of Arts & Sciences, has been named the William Warren Rhodes-Robert J. Thompson Professor of Chemistry.
A member of the Penn faculty since 1999, Dr. Walsh works in the areas of catalysis, methods development, and reaction mechanisms. From 2008 to 2018, Dr. Walsh was the Alan MacDiarmid Term Professor of Chemistry. He was elected a fellow of the Royal Society of Chemistry (UK) in 2016. Recently, Dr. Walsh was selected as one of 10 annual recipients of a 2025 Arthur C. Cope Scholar Award. The award, administered by the American Chemical Society, recognizes and encourages excellence in organic chemistry.
The Rhodes-Thompson Professorship was established in 1972 by the late William W. Rhodes, C’1910, and Mr. and Mrs. Robert J. Thompson. Mr. Rhodes and Mr. Thompson were close friends and business associates at the DuPont Company for more than 30 years. They chose to commemorate their long working relationship and advance the study of chemistry through this professorship.
School of Arts & Sciences Launches Plant Adaptability and Resilience Center
Penn Arts & Sciences has launched the Plant Adaptability and Resilience Center, or Plant ARC. The center, led by Doris Wagner, the DiMaura Professor of Biology, aims to enhance plant development and fortitude in the face of climate change, which impacts food security, human health, and ecosystems through evermore extreme and unpredictable weather events like heatwaves, droughts, and floods. Anchored in the department of biology, Plant ARC will collaborate broadly across departments and with schools and centers across Penn, as well as with local stakeholders, and beyond.
“Penn is the ideal place for Plant ARC because of its commitment to climate change solutions across schools and disciplines,” Dr. Wagner said. “Plants sustain all life on Earth and are crucial for ecosystems and climate regulation. By safeguarding essential species interactions, understanding how climate change affects plant physiology and development, and developing climate-resistant crops, Plant ARC will devise scalable, research-driven solutions that boost food security and ecosystem resilience, from urban farms in Philadelphia to global agricultural systems.”
To facilitate its research, Plant ARC will build phytotrons, programmable climate chambers that will allow Plant ARC team members to simulate past, current, and future climates from anywhere in the world; reproduce a given climate precisely in replicate experiments; and test plant response to successive, but different, climate exposures. The end goal is precision improvement of plant traits for agriculture and ecosystems generally and specifically in the urban setting.
“Plant ARC is a tremendously exciting idea, allowing Penn researchers to further develop fundamental plant research and to harness the resulting advances in plant adaptability and resilience against the effects of climate change,” said Mark Trodden, associate dean for the natural sciences, the Fay R. and Eugene L. Langberg Professor of Physics, and co-director of the Penn Center for Particle Cosmology. “This center represents an important pillar in our broad efforts in sustainability and climate in the School of Arts & Sciences.”
The center is involved in multiple recent and upcoming events, including the Penn Science Café: Plants on a Warming Planet, which focused on the complexity of plant responses to climate change, and the 1.5* Minute Climate Lectures during Climate Week at Penn.
Penn Global Launches Climate Security and Geopolitics Project Led by Scott Moore
Penn Global has announced the launch of the Climate Security and Geopolitics Project. Led by Scott Moore, director of China programs and strategic initiatives for Penn Global and a practice professor of political science in the School of Arts & Sciences, this research project examines how the return of great power rivalry, particularly with China, impacts international climate action. It explores both the challenges and opportunities geopolitics presents for climate mitigation and adaptation, offering a unique perspective distinct from existing work in the field of climate and environmental security.
The project will tackle questions at the intersection of geopolitics and climate action. Questions explored include how national security policies can effectively align with climate initiatives, what changes in global governance are needed to address the risk of geoengineering interventions, and how China uses its involvement in international climate issues to bolster its soft power—and what this means for for U.S. national interests.
The project also includes a student-focused component through the Penn Global-Perry World House Climate & Security Policy Fellows Program. Supported by the Carnegie Corporation of New York, the program provides Penn graduate students with exposure to public service careers focused on climate policy.
Based within Penn Global at the University of Pennsylvania and launched with the support of the Kleinman Center for Energy Policy and the Browne Center for International Politics at Penn, the Penn Global Project on Climate Security and Geopolitics will position Penn as a leading source of research and solutions at the intersection of climate policy, security, and international relations. Though rooted in rigorous research, the initiative will be aimed squarely at policymakers both in the U.S. and at the multilateral level.
To formally introduce the new project, Penn Global will host a series of launch events throughout the fall of 2024. On October 21, Penn Global partnered with Perry World House and the Center for Climate and Security to host a roundtable discussion on Geopolitics and the Future of Climate Finance, which featured Michael Weisberg, the Bess W. Heyman President’s Professor and deputy director of Perry World House; Erin Sikorsky, director of the Center for Climate and Security and a former Perry World House visiting fellow; Scott Moore; and Koko Warner, director of the International Organization for Migration Global Data Institute and a Perry World House non-resident senior advisor. The conversation took place at Penn Washington.
Scott Moore has also been named a Senior Advisor for Climate Security at the U.S. Department of Defense. In this role, which he will hold in conjunction with his current responsibilities with Penn Global, Dr. Moore will help shape U.S. government policy at the intersection of climate change and national security.
In addition to being a practice professor of political science and director of China programs and srategic initiatives, Dr. Moore is also a senior advisor to the Water Center at Penn. His primary research interests center on China, climate change, and security. Other research and teaching interests include water security and China’s role in the biotechnology sector.
Dr. Moore’s first book, Subnational Hydropolitics: Conflict, Cooperation, and Institution-Building in Shared River Basins (Oxford University Press, 2018), examines how climate change and other pressures affect the likelihood of conflict over water within countries. His latest, China’s Next Act: How Sustainability and Technology are Reshaping China’s Rise and the World’s Future (Oxford University Press, 2022), explores China’s role in global public goods provision against the backdrop of geopolitical rivalry and competition. His current research and book project focuses on how the return of great power rivalry between major economies and emitters shapes prospects for climate action at the international level.
Before joining Penn, Dr. Moore was a young professional and water resources management specialist at the World Bank Group, and an environment, science, technology, and health officer for China at the U.S. Department of State, where he worked extensively on the Paris Agreement on climate change. Dr. Moore holds doctoral and master’s degrees from Oxford University, where he was a Rhodes Scholar, and an undergraduate degree from Princeton.