Penn Medicine: $10 Million Department of Defense Grant to Combat Breast Cancer Recurrence
Rates of breast cancer survival continue to improve, thanks to advances in detection and treatment, but when breast cancer recurs—or returns after initial treatment—it is incurable. Currently, there is no way to predict who is most likely to experience a breast cancer recurrence, and for the 30 percent of women and men who do relapse, continuous and indefinite treatment is the only option for attempting to slow the cancer growth.
A research team from the Perelman School of Medicine at the University of Pennsylvania and the Abramson Cancer Center has received a $10 million grant from the Department of Defense (BC221382) to combat these challenges by finding and targeting dormant tumor cells before they can cause a recurrence of the disease. The team has also reported the results of a phase II clinical trial that showed for the first time that it is possible to detect and treat dormant tumor cells in breast cancer survivors, offering a proof-of-concept for the strategy of preventing breast cancer recurrence.
Dormant tumor cells were successfully cleared from more than 80 percent of patients across all three arms of the study, principal investigator Angela DeMichele, the Alan and Jill Miller Professor in Breast Cancer Excellence, reported on October 23 at the European Society for Medical Oncology (ESMO) Congress 2023. The new grant will support continued surveillance of patients who participated in the study, as well as several other studies led by the 2-PREVENT Breast Cancer Translational Center of Excellence, which Dr. DeMichele co-directs with Lewis Chodosh, chair of cancer biology and partnering PI on the grant, at Penn Medicine’s Abramson Cancer Center.
“Recurrence is a lifelong issue and problem for breast cancer survivors because it can happen decades after their initial treatment,” Dr. DeMichele said. “This grant will allow us to extend the research we’ve already started and continue to answer questions about what happens to people years down the line. We want to get away from ‘watchful waiting’ and move toward ‘active surveillance’ by learning how we can intervene to prevent relapse of breast cancer.”
After breast cancer treatment, dormant tumor cells continue to lay in wait in some patients. These so-called “sleeper cells,” also referred to as minimal residual disease (MRD), can reactivate years or even decades later. Once the cells begin to expand and circulate in the bloodstream, it can lead to the spread of metastatic breast cancer. Patients who have MRD are more likely to experience breast cancer recurrence and have decreased overall survival.
“The dormant/latency phase is an opportune window to intervene because we’ve found that these dormant cells are sensitive to drugs that don’t work against actively growing cancer cells,” Dr. Chodosh said. “Contrary to current thinking, drugs that are not effective against metastatic disease may be highly effective when used during the dormant phase of disease.”
Dr. Chodosh’s lab led previous work to identify the pathways that allow dormant tumor cells to survive in patients for decades and showed, in preclinical studies, that drugs targeting those pathways could eliminate dormant tumor cells. Dr. DeMichele’s team translated that research into the Phase II CLEVER study (NCT03032406), which tested several existing, FDA-approved drugs in patients who were previously treated for breast cancer and found to have MRD, but otherwise considered “cancer free.”
The breast cancer survivors in the study had all completed their cancer treatment within the last five years at the time of study enrollment and were randomized to receive one of three drug therapy regimens. Nearly half of the patients in the study had triple-negative breast cancer, which has a historic recurrence rate of 30 percent within the first five years. In the four years since the study was conducted, none of the triple-negative breast cancer patients who were treated on the study have had a breast cancer recurrence. Only two of 51 patients on the study have experienced a breast cancer recurrence to date.
The grant funding will support the continued monitoring of more than 200 patients who enrolled in CLEVER and three other studies. The research team hopes to evaluate a more sensitive test for dormant tumor cells and develop the optimal testing strategy for MRD, determine the long-term benefits of the study treatments, and learn more about how dormant cancer cells evade the immune system. In addition, the team will use patient-reported outcome (PRO) surveys to better understand patients’ perspectives on this type of active surveillance approach, including the psychological and emotional ramifications for survivors, as what some individuals find empowering may be anxiety-producing for others who want to move past their breast cancer diagnosis and treatment.
“We have a lot more work to do to prove that this approach can prevent breast cancer recurrence, but these results are encouraging and show that it’s feasible to safely detect and therapeutically target dormant disseminated tumor cells,” Dr. DeMichele said. “With the help of this grant funding, we want to be able to get to a point where we can effectively test patients for dormant cells after treatment and either reassure them that they’re likely cured, because they don’t have dormant cells, or if they do have dormant cells, provide them with an effective treatment to stop their cancer from returning.”
Penn Nursing: Rita and Alex Hillman Foundation Grant to Expand Programs for LGBTQ+ Adolescents and Their Families
Penn Nursing’s Dalmacio Dennis Flores, an assistant professor of nursing in the department of family and community health, has been awarded a 2023 grant from the Hillman Innovations in Care (HIC) program. The $600,000 grant will be used to expand a Penn Nursing-led program that supports the well-being of LGBTQ+ adolescents and their families. This grant is awarded by the Rita and Alex Hillman Foundation.
At a time when LGBTQ+ youth experience disproportionately high rates of negative mental health outcomes and confront an increasingly hostile legislative environment that threatens their access to health services, it is imperative to equip families with the skills needed to effectively communicate support to their LGBTQ+ children. Many families are unable to benefit from vetted educational resources due to lack of availability, understanding, cultural taboos, and limited, if any, contact with a trusted healthcare provider.
The HIC funding will expand Parents ASSIST (Advancing Supportive and Sexuality-Inclusive Sex Talks), a nurse-driven, community- informed, digitally accessible intervention that offers parents the practical knowledge they need to fully support LGBTQ+ children as they navigate adolescence amid a turbulent world. By breaking down longstanding hardships within LGBTQ+ science (e.g., separate programming for sexual minority vs. gender diverse youth) and recognizing the power that parents have to improve the lives of their LGBTQ+ children, this consolidated intervention is poised to make a significant impact on the health and well-being of all families with LGBTQ+ youth.
“We are thrilled about receiving this grant as it not only stands to create solutions for overlooked parenting concerns, but also because it is a result of our sustained partnerships with diverse stakeholders in Pennsylvania, Delaware, and New Jersey,” said Dr. Flores.
The HIC program, one of the Hillman Foundation’s defining initiatives, was created to accelerate the spread of evidence-based interventions that address the health and social needs of communities that experience discrimination, oppression, and indifference. These populations include Black, Indigenous, and People of Color (BIPOC), the economically disadvantaged, LGBTQ+ people, people experiencing homelessness, rural populations, refugees, and others.
Graduate School of Education Celebrates Expansion and Renovation

Summary Annual Report for University of Pennsylvania Basic Plan
This is a summary of the annual report for UNIVERSITY OF PENNSYLVANIA BASIC PLAN, EIN 23-1352685, Plan No. 028, for period January 1, 2022 through December 31, 2022. The annual report has been filed with the Employee Benefits Security Administration, as required under the Employee Retirement Income Security Act of 1974 (ERISA).
Basic Financial Statement
Benefits under the University of Pennsylvania Basic Plan (the plan) are provided by insurance and a trust fund. Plan expenses were $46,172,554. These expenses included $462,610 in administrative expenses and $45,709,944 in benefits paid to participants and beneficiaries. A total of 32,675 persons were participants in, or beneficiaries of, the plan at the end of the plan year, although not all of these persons had yet earned the right to receive benefits.
The value of plan assets, after subtracting liabilities of the plan, was $1,417,850,182 as of December 31, 2022, compared to $1,627,007,373 as of January 1, 2022. During the plan year, the plan experienced a decrease in its net assets of $209,157,191. This decrease includes unrealized appreciation and depreciation in the value of plan assets. The plan had total income of ($162,984,637), including employer contributions of $74,367,399, other contributions of $1,081,160, earnings from investments of ($234,438,272), and other income of ($3,994,924).
The total premiums paid for the plan year ending December 31,2022 were $0.
Your Rights To Additional Information
You have the right to receive a copy of the full annual report, or any part thereof, on request. The items listed below are included in that report:
- an accountant’s report;
- financial information;
- information on payments to service providers;
- assets held for investment;
- insurance information, including sales commissions paid by insurance carriers; and
- information regarding any common or collective trusts, pooled separate accounts, master trusts or 103-12 investment entities in which the plan participates.
To obtain a copy of the full annual report, or any part thereof, send a written request to:
Trustees of the University of PA
HR Retirement Plans
3451 Walnut St, 6th Floor
Philadelphia, PA 19104-6205
The charge to cover copying costs will be $0.00 for the full annual report, or $0.25 per page for any part thereof.
You also have the right to receive from the plan administrator, on request and at no charge, a statement of the assets and liabilities of the plan and accompanying notes, or a statement of income and expenses of the plan and accompanying notes, or both. If you request a copy of the full annual report from the plan administrator, these two statements and accompanying notes will be included as part of that report. The charge to cover copying costs given above does not include a charge for the copying of these portions of the report because these portions are provided without charge.
You also have the legally protected right to examine the annual report at the main office of the plan (TRUSTEES OF THE UNIVERSITY OF PA, 3451 WALNUT STREET 6TH FLOOR, PHILADELPHIA, PA 19104-6205) and at the U.S. Department of Labor in Washington, D.C., or to obtain a copy from the U.S. Department of Labor upon payment of copying costs. Requests to the department should be addressed to:
Public Disclosure Room, Room N-1513
Employee Benefits Security Administration
U.S. Department of Labor
200 Constitution Avenue, N.W.
Washington, D.C. 20210
Paperwork Reduction Act Statement
According to the Paperwork Reduction Act of 1995 (Pub. L. 104-13) (PRA), no persons are required to respond to a collection of information unless such collection displays a valid Office of Management and Budget (OMB) control number. The department notes that a federal agency cannot conduct or sponsor a collection of information unless it is approved by OMB under the PRA, and displays a currently valid OMB control number, and the public is not required to respond to a collection of information unless it displays a currently valid OMB control number. See 44 U.S.C. 3507. Also, notwithstanding any other provisions of law, no person shall be subject to penalty for failing to comply with a collection of information if the collection of information does not display a currently valid OMB control number. See 44 U.S.C. 3512.
The public reporting burden for this collection of information is estimated to average less than one minute per notice (approximately 3 hours and 11 minutes per plan). Interested parties are encouraged to send comments regarding the burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden, to the U.S. Department of Labor, Office of the Chief Information Officer, Attention: Departmental Clearance Officer, 200 Constitution Avenue, N.W., Room N-1301, Washington, DC 20210 or email DOL_PRA_PUBLIC@dol.gov and reference the OMB Control Number 1210-0040. OMB Control Number 1210-0040 (expires 03/31/2026)
Summary Annual Report for the University of Pennsylvania Matching Plan
This is a summary of the annual report for THE UNIVERSITY OF PENNSYLVANIA MATCHING PLAN, EIN 23-1352685, Plan No. 001, for period January 1,2022 through December 31, 2022. The annual report has been filed with the Employee Benefits Security Administration, as required under the Employee Retirement Income Security Act of 1974 (ERISA).
Basic Financial Statement
Benefits under the University of Pennsylvania Matching Plan (the plan) are provided by insurance and a trust fund. Plan expenses were $256,048,086. These expenses included $606,771 in administrative expenses and $255,441,315 in benefits paid to participants and beneficiaries. A total of 28,001 persons were participants in, or beneficiaries of, the plan at the end of the plan year, although not all of these persons had yet earned the right to receive benefits.
The value of plan assets, after subtracting liabilities of the plan, was $5,530,640,141 as of December 31, 2022, compared to $6,401,773,334 as of January 1, 2022. During the plan year, the plan experienced a decrease in its net assets of $871,133,193. This decrease includes unrealized appreciation and depreciation in the value of plan assets. The plan had total income of ($615,085,107), including employer contributions of $86,427,259, employee contributions of $97,277,175, other contributions of $12,862,662, earnings from investments of ($797,028,193), and other income of ($14,624,010).
The total premiums paid for the plan year ending December 31, 2022 were $0.
Your Rights To Additional Information
You have the right to receive a copy of the full annual report, or any part thereof, on request. The items listed below are included in that report:
- an accountant’s report;
- financial information;
- information on payments to service providers;
- assets held for investment;
- insurance information, including sales commissions paid by insurance carriers; and
- information regarding any common or collective trusts, pooled separate accounts, master trusts or 103-12 investment entities in which the plan participates.
To obtain a copy of the full annual report, or any part thereof, send a written request to:
Trustees of the University of PA
HR Retirement Plans
3451 Walnut St, 6th Floor
Philadelphia, PA 19104-6205
The charge to cover copying costs will be $0.00 for the full annual report, or $0.25 per page for any part thereof.
You also have the right to receive from the plan administrator, on request and at no charge, a statement of the assets and liabilities of the plan and accompanying notes, or a statement of income and expenses of the plan and accompanying notes, or both. If you request a copy of the full annual report from the plan administrator, these two statements and accompanying notes will be included as part of that report. The charge to cover copying costs given above does not include a charge for the copying of these portions of the report because these portions are provided without charge.
You also have the legally protected right to examine the annual report at the main office of the plan (TRUSTEES OF THE UNIVERSITY OF PA, 3451 WALNUT STREET 6TH FLOOR, PHILADELPHIA, PA 19104-6205) and at the U.S. Department of Labor in Washington, D.C., or to obtain a copy from the U.S. Department of Labor upon payment of copying costs. Requests to the Department should be addressed to:
Public Disclosure Room, Room N-1513
Employee Benefits Security Administration
U.S. Department of Labor
200 Constitution Avenue, N.W.
Washington, D.C. 20210
Paperwork Reduction Act Statement
According to the Paperwork Reduction Act of 1995 (Pub. L. 104-13) (PRA), no persons are required to respond to a collection of information unless such collection displays a valid Office of Management and Budget (OMB) control number. The department notes that a federal agency cannot conduct or sponsor a collection of information unless it is approved by OMB under the PRA, and displays a currently valid OMB control number, and the public is not required to respond to a collection of information unless it displays a currently valid OMB control number. See 44 U.S.C. 3507. Also, notwithstanding any other provisions of law, no person shall be subject to penalty for failing to comply with a collection of information if the collection of information does not display a currently valid OMB control number. See 44 U.S.C. 3512.
The public reporting burden for this collection of information is estimated to average less than one minute per notice (approximately 3 hours and 11 minutes per plan). Interested parties are encouraged to send comments regarding the burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden, to the U.S. Department of Labor, Office of the Chief Information Officer, Attention: Departmental Clearance Officer, 200 Constitution Avenue, N.W., Room N-1301, Washington, DC 20210 or email DOL_PRA_PUBLIC@dol.gov and reference the OMB Control Number 1210-0040. OMB Control Number 1210-0040 (expires 03/31/2026)
Summary Annual Report for Supplemental Retirement Annuity Plan of the University of Pennsylvania
This is a summary of the annual report for SUPPLEMENTAL RETIREMENT ANNUITY PLAN OF THE UNIVERSITY OF PENNSYLVANIA, EIN 23-1352685, Plan No. 002, for period January 1, 2022 through December 31, 2022. The annual report has been filed with the Employee Benefits Security Administration, as required under the Employee Retirement Income Security Act of 1974 (ERISA).
Basic Financial Statement
Benefits under the Supplemental Retirement Annuity Plan of the University of Pennsylvania (the plan) are provided by insurance and a trust fund. Plan expenses were $66,814,491. These expenses included $229,537 in administrative expenses, $66,527,614 in benefits paid to participants and beneficiaries, and $57,340 in other expenses. A total of 28,067 persons were participants in, or beneficiaries of, the plan at the end of the plan year, although not all of these persons had yet earned the right to receive benefits.
The value of plan assets, after subtracting liabilities of the plan, was $1,692,153,953 as of December 31, 2022, compared to $1,909,537,931 as of January 1, 2022. During the plan year, the plan experienced a decrease in its net assets of $217,383,978. This decrease includes unrealized appreciation and depreciation in the value of plan assets. The plan had total income of ($150,569,487), including employee contributions of $67,060,849, other contributions of $39,602,670, earnings from investments of ($252,067,493), and other income of ($5,165,513).
The total premiums paid for the plan year ending December 31, 2022 were $0.
Your Rights To Additional Information
You have the right to receive a copy of the full annual report, or any part thereof, on request. The items listed below are included in that report:
- an accountant’s report;
- financial information;
- information on payments to service providers;
- assets held for investment;
- insurance information, including sales commissions paid by insurance carriers; and
- information regarding any common or collective trusts, pooled separate accounts, master trusts or 103-12 investment entities in which the plan participates.
To obtain a copy of the full annual report, or any part thereof, send a written request to:
Trustees of the University of PA
HR Retirement Plans
3451 Walnut St, 6th Floor
Philadelphia, PA 19104-6205
The charge to cover copying costs will be $0.00 for the full annual report, or $0.25 per page for any part thereof.
You also have the right to receive from the plan administrator, on request and at no charge, a statement of the assets and liabilities of the plan and accompanying notes, or a statement of income and expenses of the plan and accompanying notes, or both. If you request a copy of the full annual report from the plan administrator, these two statements and accompanying notes will be included as part of that report. The charge to cover copying costs given above does not include a charge for the copying of these portions of the report because these portions are provided without charge.
You also have the legally protected right to examine the annual report at the main office of the plan (TRUSTEES OF THE UNIVERSITY OF PA, 3451 WALNUT STREET 6TH FLOOR, PHILADELPHIA, PA 19104-6205) and at the U.S. Department of Labor in Washington, D.C., or to obtain a copy from the U.S. Department of Labor upon payment of copying costs. Requests to the Department should be addressed to:
Public Disclosure Room, Room N-1513
Employee Benefits Security Administration
U.S. Department of Labor
200 Constitution Avenue, N.W.
Washington, D.C. 20210
Paperwork Reduction Act Statement
According to the Paperwork Reduction Act of 1995 (Pub. L. 104-13) (PRA), no persons are required to respond to a collection of information unless such collection displays a valid Office of Management and Budget (OMB) control number. The department notes that a federal agency cannot conduct or sponsor a collection of information unless it is approved by OMB under the PRA, and displays a currently valid OMB control number, and the public is not required to respond to a collection of information unless it displays a currently valid OMB control number. See 44 U.S.C. 3507. Also, notwithstanding any other provisions of law, no person shall be subject to penalty for failing to comply with a collection of information if the collection of information does not display a currently valid OMB control number. See 44 U.S.C. 3512.
The public reporting burden for this collection of information is estimated to average less than one minute per notice (approximately 3 hours and 11 minutes per plan). Interested parties are encouraged to send comments regarding the burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden, to the U.S. Department of Labor, Office of the Chief Information Officer, Attention: Departmental Clearance Officer, 200 Constitution Avenue, N.W., Room N-1301, Washington, DC 20210 or email DOL_PRA_PUBLIC@dol.gov and reference the OMB Control Number 1210-0040. OMB Control Number 1210-0040 (expires 03/31/2026)