NIA Awards $6.9 Million to PSOM to Advance Potential Alzheimer’s Disease Treatment
A multidisciplinary team of scientists led by Kurt Brunden at the Perelman School of Medicine, and Carlo Ballatore at University of California San Diego, has been awarded a $6.9 million grant from the National Institute on Aging (NIA) to prepare a potential disease-modifying Alzheimer’s treatment for future clinical trials. In a recently published study about the new compound, called CNDR-51997, the team found it was effective in restoring brain health in mouse models of Alzheimer’s disease. CNDR-51997 was identified through a joint drug discovery program at Penn and UC San Diego that was supported by grants from the NIA.
The new grant will help the researchers demonstrate the drug’s safety in the formal studies required by the U.S. Food and Drug Administration (FDA) before the initiation of human testing. By the end of the three-year grant period, the researchers hope to submit an Investigational New Drug (IND) application to the FDA, which, if approved, would allow for Phase 1 clinical studies.
Alzheimer’s disease is characterized by abnormal deposits of two types of protein in the brain: amyloid beta (Aβ) and tau. The only currently available disease-modifying treatments for Alzheimer’s, lecanemab (Leqembi) and donanemab (Kisunla), target Aβ deposits in the brain. Notably, there are currently no approved therapies that target pathological tau. In mice, the researchers found that CNDR-51997 was able to reduce both Aβ plaques and tau pathology in the brain.
In addition to Alzheimer’s, there are several other diseases characterized by tau pathology, such as traumatic brain injury, chronic traumatic encephalopathy (CTE), frontotemporal lobar degeneration, progressive supranuclear palsy, corticobasal degeneration, and Pick’s disease. The researchers believe that their compound could not only be a future treatment for Alzheimer’s, but also for these other related diseases, collectively called tauopathies.
“Our findings that CNDR-51997 reduces both Aβ plaques and tau inclusions in mouse models suggest that the compound holds considerable promise for Alzheimer’s disease,” said Dr. Brunden, a research professor and the director of drug discovery at Penn’s Center for Neurodegenerative Disease Research. “However, there is also a great unmet need for disease-modifying drugs for the other tauopathies. The potential of CNDR-51997 to address tau-related diseases beyond Alzheimer’s is another important aspect of its therapeutic promise.”
One of the functions of tau is to stabilize microtubules, dynamic tube-like structures that help give cells their shape. In neurons, microtubules play an important role in axonal transport, a process in which proteins and other cellular constituents are distributed to different parts of the long axonal extensions that are involved in brain function.
In Alzheimer’s disease and other tauopathies, tau becomes detached from microtubules, which causes them to become disorganized. This leads to axonal transport deficits and neuronal loss. In preclinical studies, the new compound CNDR-51997 was able to correct these imbalances, ultimately reducing both Aβ and tau pathologies.
“Alzheimer’s is a devastating disease with very few treatment options, so we are eager to advance CNDR-51997 through the drug development process,” said Dr. Ballatore, a professor at UC San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences. “This compound has been designed to combat tau-mediated neurodegeneration and our preclinical data suggest that it could be beneficial for the treatment of Alzheimer’s and related dementias.”
Brady Beale and Barbara Dallap-Schaer: Associate Deans at Penn Vet

The Gilbert S. Kahn Dean of Veterinary Medicine, Andrew M. Hoffman, has announced the appointment of two new associate deans at the school’s veterinary hospitals. These new appointments signify the invaluable impact hospital services have on the school’s three-part mission.
Brady Beale, an associate professor of ophthalmology and Ryan Hospital’s director and chief medical officer, has been appointed to associate dean of clinical enterprise. In this role, she will oversee the management and operations of Ryan Hospital, including future development and implementation of strategic plans; deliver patient-centric care that meets the high clinical training standards for students, interns, residents, and fellows; and guide an environment that is conducive to clinical research and trials.
Barbara Dallap-Schaer, a professor of surgery and emergency & critical care medicine, and hospital director of New Bolton Center, has been appointed associate dean for clinical education and operations for New Bolton Center.
As associate dean, she will oversee strategic direction for the large animal hospital; prioritize competency-based veterinary education; and optimize clinical rotation educational experiences at New Bolton Center.
These new appointments ensure the development and continued success of the school’s small and large animal hospitals and clinical services, and support Penn Vet’s compelling vision for the future of veterinary medicine.
Weitzman Faculty Earn Ramboll Foundation Grant to Tackle the Global Urban Heat Crisis with Innovative Cooling Technology
Weitzman faculty members have been selected to receive $149,000 in funding from the Ramboll Foundation to develop an accessible solution to tackle urban heat. The team will partner with architectural firm Henning Larsen to develop KlimaKover, an innovative architectural application of membrane-assisted radiant cooling technology designed for climate resiliency.
The funding will be used to create a prototype external autonomous pavilion or an indoor replicable element, providing scalable solutions for emergency situations, and for communities susceptible to the urban heat island (UHI) effect.
As global temperatures soar, cities worldwide are grappling with the effects of extreme heat, projected to persist for nearly half the year. Exposure to these dangerous heat levels has increased by 200% since the 1980s, disproportionately affecting low-income and marginalized communities and exacerbating social inequalities. The traditional air conditioner market is predicted to grow by 1 billion units before the end of the decade, straining local power supplies, contributing to waste heat issues, and ultimately exacerbating global warming.
Designed to break this cycle, KlimaKover uses a membrane-assisted radiant cooling technology, which was developed by an international team of researchers from institutions in the U.S., Canada, Asia, and Europe, that provides low-energy cooling while allowing for natural ventilation.
“I’ve been fortunate to be part of a major cross-institutional research effort to make radiant cooling possible throughout the globe as an alternative to air conditioning, with the goal of achieving a sustainable and healthy form of cooling,” said Dorit Aviv, an assistant professor of architecture in the Weitzman School and director of the Thermal Architecture Lab. “This grant from the Ramboll foundation and collaboration with Henning Larsen, has the potential to make this technology accessible and deployable in the places that need it the most.”
The proposed solution takes the shape of a mobile, deployable, and autonomous structure designed for disassembly which can be transported to various locations and tested on developer partner sites. This is a low-energy consuming, condensation-free, radiant comfort product that can function in cooling or heating modes.
“As the impact of climate change becomes more severe, investment in innovative technologies for better climate resilience is crucial, and ensuring a more equitable approach to addressing and adapting to these challenges is vital,” said Kritika Kharbanda, head of sustainability at Henning Larsen. “We are so excited to take this forward with our partners Penn and Ramboll.”
The Weitzman team includes Dorit Aviv, an assistant professor of architecture; William Braham, the Andrew Gordon Professor of Architecture; and Eric Teitelbaum, a lecturer in architecture. The partnership between Penn, Henning Larsen, and Ramboll marks their first collaboration. Having secured significant funding, they are joining forces for innovation with a focus on design thinking and scalability. Also joining the project are collaborators from Princeton University and the University of British Columbia, who have led the development of the membrane-assisted radiant cooling technology. The project aims to deliver a prototype that demonstrates the technology’s potential by summer 2025.
Penn Association of Senior and Emeritus Faculty 2024 Annual Report
PASEF, the Penn Association of Senior and Emeritus Faculty, is the organization of and for senior (age 55+) and emeritus and retired faculty from all schools and colleges of the University. PASEF encompasses both standing faculty and associated faculty with the rank of associate and full professor on the academic clinician, research, and practice tracks. Per its mission statement, PASEF “informs and advocates on matters of concern to senior and retired faculty through dialogue with the University administration and communication with its members and the larger community.”
PASEF shares important information relevant to senior and emeritus faculty with its members and engages with the administration when matters of concern to the membership arise. PASEF also does much more—see below. The core mission, however, is service to faculty retirees and faculty approaching retirement and advocacy on their behalf. The PASEF officers meet periodically with the Vice Provost for Faculty to discuss issues of concern. We thank Vice Provost Laura Perna for her assistance and willingness to respond to the concerns of retired faculty.
In the fall, the PASEF officers devoted substantial time to understanding the new FIAP program, which was suddenly announced in early September. Various means were used to communicate this to PASEF members, including a special panel discussion (via Zoom) on October 24. We regularly respond to member questions and provide information when we perceive that members may not be fully aware of how to access benefits—for example, the hearing aid benefit.
PASEF Size and Scope
PASEF’s membership is large and largely Philadelphia-based. As of July 26, 2024, PASEF had 2,214 members, including 1,345 senior faculty and 869 retired faculty. Of the retirees, 693 remain in the Philadelphia area.
The PASEF Council meets monthly throughout the academic year and attendance at council meetings is high, averaging 85–90%. Our meetings are hybrid, thus allowing those members who live far from Philadelphia or those travelling to participate. PASEF members sit ex-officio on the Faculty Senate Executive Committee and four of the standing committees of the Faculty Senate: Faculty Development, Diversity, and Equity; Faculty and the Academic Mission; Faculty and the Administration; and Students and Educational Policy. PASEF designates a member of Penn’s Committee on Personnel Benefits. And PASEF’s president sits on the Executive Council of our school-based organization, the Association of Senior and Emeritus Faculty of the Perelman School of Medicine (ASEF-PSOM).
PASEF Activities
PASEF’s principal activities consist of membership programs, membership engagement and communication, community service, and engagement with the Penn administration.
Membership programs. PASEF offers retirement-related, academic, and cultural programs for its members. This past year’s retirement-related programs included New FIAP—What are the Issues? (October 24), Exploring Living Options in Retirement (December 6), Medicare and Social Security: Concerns of Retiring and Retired Faculty (January 16), Estate Planning—Special Needs (March 26), The Nuts & Bolts of Retirement (April 25), and our annual Newly Retired & Emeritus Faculty Celebration (May 6).
PASEF’s retirement-related programs draw the largest audiences, around 100 a piece on Zoom. This past year the most popular was New FIAP—What are the Issues?
Our fall speaker event featured Claire Finkelstein on September 2 speaking about Defendant-in-Chief: Understanding the Trump Indictments and the Stakes for U.S. Democracy.
Our academic programs were Christian Terwiesch’s Would ChatGPT get a Wharton Degree? on October 26, Chris Callison-Burch’s Ask an Expert About ChatGPT and Its Potential Uses in Education (November 8), Can You Hear Me Now? An Introduction to Hearing Loss and Hearing Aids with Diane Holstein, AuD, Danielle Leibowitz, AuD, and Stacy Douberly, AuD (February 29); Guthrie P. Ramsey, Jr.’s What I Did with Musicology and What It Gave Me Back (March 14); and Olivia Mitchell’s Longevity Awareness (April 9).
Many people contribute to the success of PASEF’s programs, too many to list, but special thanks go to PASEF Program Committee chair Andy Binns and members Ed George, Eduardo Glandt, and Ann O’Sullivan, who worked tirelessly to make our programs happen.
Membership engagement and communication. Membership in PASEF is automatic, but ongoing engagement of our membership depends on effective communication. Currently, PASEF has three key channels of communication: The Hitchhiker’s Guide to Faculty Retirement, PASEF e-newsletters, and the PASEF website.
PASEF’s flagship publication is The Hitchhiker’s Guide to Faculty Retirement, now in its 16th edition. Though not an official publication of the University, the Hitchhiker’s Guide has become the de facto retirement manual for Penn faculty. This year’s membership survey indicated that the Hitchhiker’s Guide is considered an invaluable source of information for those nearing retirement. Annual updates and release notes are published each year, usually in January, although this year it was somewhat delayed due to the extensive changes made to FIAP. Martin Pring and Janet Deatrick have ably managed annual revisions of the Hitchhiker’s Guide.
Nine PASEF e-newsletters were sent to members in the 2023-2024 academic year. We also sent one news flash. The newsletter highlights upcoming PASEF activities and, in the president’s column, alerts members to upcoming deadlines and changes in benefits, benefits administration, and other issues affecting retirees. This year’s membership survey revealed that our newsletter has the greatest reach, with 85% of respondents reporting that they read it at least occasionally.
Privileges of retired members of the associated faculty. Last year we were alerted that some retired associated faculty had problems concerning library privileges. Some other issues cropped up this year, and we have been endeavoring to get a full picture of the situation. Unlike for retired standing faculty, whose privileges are listed in the Faculty Handbook, privileges for retired associated faculty are left to the individual schools, which has seemingly led to some variation. In addition, certain issues require follow-up, including consistent coding of associated faculty in Workday upon retirement and the interface between Workday and the Penn community system.
PASEF Council and Committees. A list of 2023-2024 PASEF Council and committee members is appended. Thanks to all and especially to past president Marshall Meyer and president-elect Mitch Marcus for their counsel and support throughout.
In Memoriam. At every PASEF Council meeting, we note the passing of Penn faculty members and reminisce about their time at Penn. This year we sadly noted the passing of Anita Summers, who served as PASEF president from 2015-2016.
—Janice R. Bellace
2023-2024 PASEF President
Appendix: 2023-24 PASEF Council Members
- Sherrill L. Adams–Dental Medicine (Biochemistry)-at-large member of Council; Faculty Development, Diversity & Equity (SCFDDE) representative
- Gustavo Aguirre–Penn Vet (Clinical Sciences & Advanced Medicine)-at-large member of Council
- Roger M. A. Allen–Arts & Sciences (Near Eastern Languages and Civilizations)-representative to Faculty and the Academic Mission (SCOF)
- Janice Bellace–Wharton (Legal Studies & Business Ethics)–president; chair of Steering Committee
- Andrew N. Binns–Arts & Sciences (Biology)-at-large member of Council; chair, Program Committee
- Peter Conn–Arts & Sciences (English)-library liaison
- Janet Deatrick–Nursing (Family & Community Health)-co-editor of The Hitchhiker’s Guide to Faculty Retirement; representative to Senate Executive Committee (SEC)
- Edward I. George–Wharton (Statistics and Data Science)-at-large member of Council
- Peter Kuriloff–Graduate School of Education–secretary; representative to University Council Committee on Personnel Benefits (PBC)
- Mitch Marcus–Engineering & Applied Science (Computer and Information Science)-president-elect; chair, Nominating Committee; co-chair, Community Involvement Committee
- Marshall W. Meyer–Wharton (Management)–past president; chair, Membership Engagement Committee
- Charles Mooney, Jr.–Penn Carey Law-at-large member of Council; pepresentative to Faculty and the Administration (SCOA)
- Ana Lía Obaid–Penn Medicine (Neuroscience)-at-large member of Council; co-chair, Community Involvement Committee
- Ann L. O’Sullivan–Nursing (Family & Community Health)-at-large member of Council
- Martin Pring–Penn Medicine (Physiology)-co-editor of The Hitchhiker’s Guide to Faculty Retirement
- Brian M. Salzberg–Penn Medicine (Neuroscience)-at-large member of Council
- Irene Wong–Social Policy & Practice-at-large member of Council; representative to Students & Educational Policy (SCSEP)
- Former Presidents: Gerald J. Porter, Neville E. Strumpf, Roger M. A. Allen, Ross A. Webber, Jack H. Nagel, Anita A. Summers, Paul Shaman, Lois K. Evans, Janice F. Madden, and Janet Deatrick