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IME $6.7 Million Bioengineering Grant

The NIH National Heart Lung and Blood Institute has awarded an interdisciplinary research grant to Institute for Medicine and Engineering (IME) investigators led by Dr. Peter F. Davies. The grant, totaling $6.7 million over five years, focuses on the biomechanics of cardiovascular cells, membranes, and molecules with emphasis on how these properties determine and control cardiovascular tissue function. The partnership is composed of two interactive components: fundamental cell and molecular investigations of cardiovascular mechanotrans-duction, and preclinical studies of engineered arteries, heart valve calcification, and microcoil treatment of intracranial aneurysms.

Complementary experimental approaches that are both design-driven and hypothesis-driven include geometric constraints, spatial analyses, protein conformational changes, deformation properties of molecules and membranes, and mass transport characteristics that regulate vascular cell structure, gene expression, function, and maladaptation to blood flow forces leading to pathological change.

The integrative group of IME investigators is Dr. Peter F. Davies, director, IME, professor of pathology and laboratory medicine, SOM, and bioengineering, SEAS; Dr. Scott L. Diamond, associate professor of chemical engineering, and bioengineering, SEAS, and pharmacology, SOM; Dr. Dennis E. Discher, associate professor of mechanical engineering and applied mechanics, bioengineering, and chemical engineering, SEAS; Dr. Keith J. Gooch, assistant professor of bioengineering, SEAS; Dr. Daniel A. Hammer, professor and chair, bioengineering and chemical engineering, SEAS; Dr. Paul A. Janmey, professor of physiology, SOM, bioengineering, SEAS, and physics, SAS; Dr. Irena Levitan, research assistant professor of pathology & laboratory medicine, SOM; Dr. Valerie M. Weaver, assistant professor of pathology and laboratory medicine, SOM; and Dr. Robert J. Levy, professor of pediatrics and senior scientist at the Stokes Research Institute, CHOP.

Almanac, Vol. 48, No. 8, October 16, 2001


October 16, 2001
Volume 48 Number8

The grand old Quad will have three new College Houses when renovations are complete next fall.
Getting around University City will be easier for pedestrians and motorists thanks to new signage.
A $6.7 million NIH grant has been awarded to the Institute for Medicine and Engineering.
President Rodin will receive the Beacon Award at the upcoming celebration of 125 Years of Women at Penn.
Professor Peter Stallybrass will receive the MLA's Lowell Prize for most outstanding literary or linguistic study.
La Casa Latina: the Center for Hispanic Excellence has a new director.
The ICA has a new director of marketing and communications.
A new Entrepreneur in Residence program gives students a chance to meet and mingle with experienced entrepreneurs.
Research in the social and behavioral sciences involving human subjects must be reviewed by Penn's Institutional Review Board.