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State-of-the-Art Genome Analyzer
May 6, 2008, Volume 54, No. 32

The Penn Genome Frontiers Institute (PGFI) and the Penn Microarray Facility are pleased to announce the acquisition of an Illumina Solexa Genome Analyzer, version GA-II. The Genome Analyzer system is powered by Illumina Sequencing technology, which uses a massively parallel sequencing-by-synthesis approach to generate billions of bases of high-quality DNA sequence per run; this system can perform tens of millions of sequencing reactions in parallel at less than 1% of the cost of capillary-based methods (www.illumina.com/pages.ilmn?ID=204).

 This state-of-the-art analyzer also includes a paired-end module, allowing extra sequencing runs from the opposite end of the template. Applications of this technology include discovery and quantitation of RNA transcripts and microRNAs, sequence-tag counting from libraries of genomic DNA fractions, and targeted resequencing to identify genetic variants.

Researchers interested in utilizing the Illumina Genome Analyzer for high-throughput sequencing, should contact Dr. Don Baldwin at (215) 898-3675 or dbaldwin@mail.med.upenn.edu. Prices are based on a combination of Microarray Facility labor and reagent fees. A discount is available for all PGFI members. Information about using the Facility is available at www.med.upenn.edu/bmcrc.








Almanac - May 6, 2008, Volume 54, No. 32